hLife 2024年第一期正式出版

Volume 2  Issue 1

    封 面 解 读

施一

The scientists want to find the Achilles’ heel of the emerging viruses, and then develop countermeasures against the key targets. In this issue, Shi and his colleagues have solved the crystal structures of RNA-dependent RNA polymerase (RdRp) from segmented Jingmeng viruses and identified the key region of the virus genome responsible for the binding and activity of RdRp. They revealed the common and specific structural features that will provide an important basis for drug development against segmented flaviviruses. Moreover, Zhong and his colleagues have assessed the risk of Bombali virus spillover to humans and found that although wild-type BOMV does not efficiently infect human cells, the emergence of mutations in viral GP may boost its ability to spill over to humans. Wang, Gao, and their colleagues have shown that the fusion peptide inhibitor HY3000 is still working against emerging SARS-CoV-2 EG.5, EG.5.1, and BA.2.86 variants.

目     录

导     读

1.Medical Journals in China: From Wuyi Huijiang to Chinese Medical Journal and hLife

通讯作者：闫群

引用：

Yan Q, Shi Y, Gao GF. Medical Journals in China: From Wuyi Huijiang to Chinese Medical Journal and hLife. hLife 2024;2:1–3. doi:https://doi.org/10.1016/j.hlife.2023.08.001

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2. Is the time right for systematically serotyping SARS-related coronaviruses?

通讯作者：王林发 

引用：

Tan CW, Wang LF. Is the time right for systematically serotyping SARS-related coronaviruses? hLife 2024;2:4-5. doi:https://doi.org/10.1016/j.hlife.2023.12.007

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3. Advances in the pathogenic, genetic and immunological studies of leprosy

通讯作者：刘红、张福仁

引用：

Mi Z, Liu H, Zhang F. Advances in the pathogenic, genetic and immunological studies of leprosy. hLife 2024;2:6–17. doi: https://doi.org/10.1016/j.hlife.2023.10.003

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4. Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus

通讯作者：施一

Highlights

•High-resolution structures of RNA dependent RNA polymerases (RdRps) from Jingmen tick virus (JMTV) and Alongshan virus (ALSV).

•The structures of JMTV and ALSV RdRps are similar to those from the typical Flavivirus genus.

•The JMTV and ALSV RdRps lack typical zinc-binding pockets of flaviviruses and harbor much shorter region B–C.

•A conserved 8-nucleotide element of stem loop A was essential to bind with RdRp and perform de novo replication activity.

引用：

Liu Z, Peng Q, Han P, et al. Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus. hLife 2024;2:18-31.

doi:https://doi.org/10.1016/j.hlife.2023.10.006

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5. Assessing risk of Bombali virus spillover to humans by mutagenesis analysis of viral glycoprotein

通讯作者：钟劲

Highlights

•Wild-type Bombali virus (BMOV) glycoproteins (GPs) do not efficiently mediate viral entry into human cells.

•Mutations in the receptor binding domain (RBD) of BOMV GPs improve the viral entry.

•Mutations in the RBD of BOMV GPs enhance the GP's binding to human NPC1.

引用：

Li L, Gan T, Ma Z, et al. Assessing risk of Bombali virus spillover to humans by mutagenesis analysis of viral glycoprotein. hLife 2024;2:32-42. doi:https://doi.org/10.1016/j.hlife.2023.11.003

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6. Efficient inhibition of SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants by fusion inhibitor HY3000 peptide

通讯作者：王奇慧

引用：

Wu L, Zheng A, Tang Y, et al. Efficient inhibition of SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants by fusion inhibitor HY3000 peptide. hLife 2024;2:43–46.  doi:https://doi.org/10.1016/j.hlife.2023.10.002

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